Search results for "Chiralpak AD"

showing 2 items of 2 documents

Enantiomerization of an inherently chiral resorcarene derivative: determination of the interconversion barrier by computer simulation of the dynamic …

2001

Abstract The inherently chiral tetrabenzoxazine resorcarene derivative 1 shows characteristic plateau-formation during enantioselective HPLC separation on the chiral stationary phase Chiralpak AD. By computer assisted peak form analysis of the elution profiles, obtained from temperature dependent dynamic HPLC (DHPLC) experiments, with ChromWin, the enantiomerization barrier Δ G # (298 K)=92±2 kJ mol −1 and the activation parameters Δ H # =53.0±1.8 kJ mol −1 and Δ S # =−131±14 J (K mol) −1 were determined.

ElutionOrganic ChemistryAnalytical chemistryForm analysisChiralpak ADResorcinareneChiral stationary phaseHigh-performance liquid chromatographyCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryPhysical and Theoretical ChemistryEnantioselective hplcDerivative (chemistry)Tetrahedron: Asymmetry
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Resolution of inherently chiral resorcarene derivatives by enantioselective HPLC

1999

Abstract The HPLC enantiomeric resolution of five inherently chiral tetrabenzoxazine derivatives of resorcarenes has been achieved by HPLC using Whelk-Ol and in one case Chiralpak AD as stationary phases. Enantiomeric separation was only observed in a very narrow range of mobile phase compositions. On-column enantiomeric interconversion of a racemic compound with a typical plateau-like elution profile was observed using a Chiralpak AD column

ChromatographyResolution (mass spectrometry)ElutionChemistryOrganic ChemistryDrug DiscoveryNarrow rangeChiralpak ADEnantiomerResorcinareneBiochemistryEnantioselective hplcHigh-performance liquid chromatographyTetrahedron Letters
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